TABLE 1

Mean ± S.E.M. ED50 values calculated from ethanol dose-response functions generated during generalization testing at 24 or 16 h following an increasing amount of chronic ethanol exposure delivered in an intermittent (MW condition) or continuous (CE condition) manner

Repeated ED50 determinations for the CTL group were collapsed for analysis. Discrimination training was suspended during chronic inhalation treatment.

Group
ED50 Values at 24 h
ED50 Values at 16 h
g/kg
Control 0.67 ± 0.03 0.67 ± 0.03
MW×1 1.03 ± 0.05*
MW×2 0.94 ± 0.04* 1.62 ± 0.07*‡
MW×3 0.98 ± 0.05*
MW×4 1.35 ± 0.07* 2.15 ± 0.14*‡
CE/16 0.96 ± 0.04*
CE/32 1.23 ± 0.04*† 1.44 ± 0.07*†‡
CE/48 1.28 ± 0.05*†
CE/64
1.36 ± 0.07*
1.77 ± 0.12*†‡

  • ↵* Significantly differs from controls (P < 0.01).

  • ↵† Significantly differs from corresponding MW group (P < 0.05).

  • ↵‡ Significantly differs from corresponding group tested at 24 h (P < 0.001).