Effects of different drugs on EFS-evoked gallbladder contractions
Young Adults | Aged | Melatonin | |
|---|---|---|---|
| Atropine (10 μM) | Abolition P < 0.001 | Abolition P < 0.001 | Abolition P < 0.001 |
| l-NAME (100 μM) | Increase P < 0.01 | No effect P = 0.824 | Increase P < 0.001 |
| Capsaicin (10 μM) | No effect P = 0.338 | Increase P < 0.01 | No effect P = 0.386 |
| Glibenclamide (10 μM) | No effect P = 0.913 | Increase P < 0.05 | Not tested |
| Glibenclamide + Capsaicin | No effect P = 0.38 | No effect P = 0.178 | No effect P = 0.178 |
| CGRP8-32 (1 μM) | Not tested | Increase P < 0.05 | Not tested |
| CGRP8-32 + Capsaicin | Not tested | Decrease P < 0.01 | Not tested |
* Significance by two-way ANOVA.