Desensitization/activation ratios for SP and RTKC at rat and human NK1 receptors
The EC50s for SP and RTKC to elicit calcium responses and desensitization of the rat and human NK1 receptors are shown. The desensitization/activation ratio is calculated as the EC50 for signal activation divided by the EC50 for desensitization.
Peptide | Rat NK1 Receptor (EC50) | Desensitization/Activation Ratio | Human NK1 Receptor (EC50) | Desensitization/Activation Ratio | ||||
|---|---|---|---|---|---|---|---|---|
| Signal activation | Desensitization | Signal activation | Desensitization | |||||
| nM | nM | |||||||
| SP | 2.6 | 0.9 | 0.35 | 10.0 | 2.5 | 0.25 | ||
| RTKC | 7.3 | 50.6 | 6.93 | 15.3 | 29.2 | 1.93 | ||