Assigned or fitted parameters from force-fitting of the E217G and E23S17G data from the in situ recirculating perfused metastatic and sham-operated rat liver preparations at 4 weeks postinoculation with a physiological model
Data are fitted parameters ± S.D.
Parameters | CLef = 0 (WF = 0) | CLef > 0 (WF = 0) | ||||
|---|---|---|---|---|---|---|
| Sham-Operated Livers | Tumor Livers | Sham-Operated Livers | Tumor Livers | |||
| Influx clearance of E217G, CLin (ml/min) | 546 ± 172 | 283 ± 50 | 545 ± 174 | 284 ± 51 | ||
| Efflux clearance of E217G, CLef (ml/min) | 0 | 0 | 6 × 10-15 ± 1.5 × 10-10 | 6 × 10-15 ± 1.5 × 10-10 | ||
| Sulfation intrinsic clearance of E217G, CLint,sult (ml/min) | 2.56 ± 1.94 | 3.69 ± 2.79 | 2.73 ± 2.16 | 3.93 ± 3.10 | ||
| Desulfation intrinsic clearance of E23S17G, CLint,desult{M} (ml/min) | 1.19 ± 0.62 | 1.19 ± 0.62 | 1.22 ± 0.62 | 1.22 ± 0.62 | ||
| Biliary intrinsic clearance of E217G, CLint,sec (ml/min) | 1.55 ± 0.61 | .55 ± 0.61 | 1.60 ± 0.68 | 1.60 ± 0.68 | ||
| Biliary intrinsic clearance of E23S 17G, CLint,sec{M} (ml/min) | 0.88 ± 0.27 | 0.88 ± 0.27 | 0.85 ± 0.27 | 0.85 ± 0.27 | ||
| Model selection criterion | 4.01 | 4.01 | 3.98 | 3.98 | ||
| F test | -0.00015 < F(1,58) = 4.0 | -0.00015 < F(1,58) = 4.0 | -0.00015 < F(1,58) = 4.0 | -0.00015 < F(1,58) = 4.0 | ||