Mature Form (55 kDa) | Immature Form (45 kDa) | |
---|---|---|
Maturation extent (×107, AUC, digital light unit × hour) | ||
Vehicle | 3.27 ± 0.22 | |
Naloxone | 4.03 ± 0.28* | |
Generation rate constant (ka, hour-1) | ||
Vehicle | 1.46 ± 0.20 | |
Naloxone | 1.81 ± 0.09 | |
Peak time (tmax, hour) | ||
Vehicle | 1.95 ± 0.19 | |
Naloxone | 1.52 ± 0.23 | |
Turnover rate constant (ke, hour-1) | ||
Vehicle | 0.092 ± 0.002 | 1.37 ± 0.13 |
Naloxone | 0.094 ± 0.004 | 1.97 ± 0.14* |
Half-life (t1/2, hour) | ||
Vehicle | 7.57 ± 0.12 | 0.52 ± 0.04 |
Naloxone | 7.42 ± 0.32 | 0.36 ± 0.03* |
↵* P < 0.05 compared with the control using a two-tailed Student's t test.