TABLE 2

Effects of i.c.v. treatment with acetyl-l-carnosine or l-histidine on histopathological changes in the kidneys of ARF rats 24 h after I/R

Values represent the mean ± S.E.M. (n = 6) of histopathological grade. Grade: no change (0), mild (1), moderate (2), severe (3), and very severe (4).

Experimental Group
Proteinaceous Casts in Tubuli
Medullary Congestion
Tubular Necrosis
ARF + vehicle i.c.v. 3.50 ± 0.22 3.33 ± 0.33 3.50 ± 0.34
ARF + acetyl-l-carnosine 5 pmol/rat i.c.v. 3.33 ± 0.21 3.33 ± 0.42 3.17 ± 0.31
ARF + l-histidine 5 pmol/rat i.c.v.
1.33 ± 0.42**
1.50 ± 0.43**
1.67 ± 0.21**

  • ↵** P < 0.01, compared with vehicle-treated ARF rats.