RT Journal Article SR Electronic T1 S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis JF Journal of Pharmacology and Experimental Therapeutics JO J Pharmacol Exp Ther FD American Society for Pharmacology and Experimental Therapeutics SP 359 OP 370 DO 10.1124/jpet.116.233205 VO 358 IS 2 A1 Anna Cantalupo A1 Annarita Di Lorenzo YR 2016 UL http://jpet.aspetjournals.org/content/358/2/359.abstract AB Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids are now recognized as important bioactive signaling molecules that modulate a variety of cellular functions, including those relevant to cancer and immunologic, inflammatory, and cardiovascular disorders. In this review, we discuss recent advances in our understanding of the role of sphingosine-1-phosphate (S1P) receptors in the regulation of vascular function, and focus on how de novo biosynthesized sphingolipids play a role in blood pressure homeostasis. The therapeutic potential of new drugs that target S1P signaling is also discussed.