TY - JOUR T1 - S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 359 LP - 370 DO - 10.1124/jpet.116.233205 VL - 358 IS - 2 AU - Anna Cantalupo AU - Annarita Di Lorenzo Y1 - 2016/08/01 UR - http://jpet.aspetjournals.org/content/358/2/359.abstract N2 - Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids are now recognized as important bioactive signaling molecules that modulate a variety of cellular functions, including those relevant to cancer and immunologic, inflammatory, and cardiovascular disorders. In this review, we discuss recent advances in our understanding of the role of sphingosine-1-phosphate (S1P) receptors in the regulation of vascular function, and focus on how de novo biosynthesized sphingolipids play a role in blood pressure homeostasis. The therapeutic potential of new drugs that target S1P signaling is also discussed. ER -