%0 Journal Article %A Anna Cantalupo %A Annarita Di Lorenzo %T S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis %D 2016 %R 10.1124/jpet.116.233205 %J Journal of Pharmacology and Experimental Therapeutics %P 359-370 %V 358 %N 2 %X Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids are now recognized as important bioactive signaling molecules that modulate a variety of cellular functions, including those relevant to cancer and immunologic, inflammatory, and cardiovascular disorders. In this review, we discuss recent advances in our understanding of the role of sphingosine-1-phosphate (S1P) receptors in the regulation of vascular function, and focus on how de novo biosynthesized sphingolipids play a role in blood pressure homeostasis. The therapeutic potential of new drugs that target S1P signaling is also discussed. %U https://jpet.aspetjournals.org/content/jpet/358/2/359.full.pdf