@article {Cantalupo359, author = {Anna Cantalupo and Annarita Di Lorenzo}, title = {S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis}, volume = {358}, number = {2}, pages = {359--370}, year = {2016}, doi = {10.1124/jpet.116.233205}, publisher = {American Society for Pharmacology and Experimental Therapeutics}, abstract = {Initially discovered as abundant components of eukaryotic cell membranes, sphingolipids are now recognized as important bioactive signaling molecules that modulate a variety of cellular functions, including those relevant to cancer and immunologic, inflammatory, and cardiovascular disorders. In this review, we discuss recent advances in our understanding of the role of sphingosine-1-phosphate (S1P) receptors in the regulation of vascular function, and focus on how de novo biosynthesized sphingolipids play a role in blood pressure homeostasis. The therapeutic potential of new drugs that target S1P signaling is also discussed.}, issn = {0022-3565}, URL = {https://jpet.aspetjournals.org/content/358/2/359}, eprint = {https://jpet.aspetjournals.org/content/358/2/359.full.pdf}, journal = {Journal of Pharmacology and Experimental Therapeutics} }