TY - JOUR T1 - Interactions between Bupropion and 3,4-Methylenedioxymethamphetamine in Healthy Subjects JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 102 LP - 111 DO - 10.1124/jpet.114.222356 VL - 353 IS - 1 AU - Yasmin Schmid AU - Anna Rickli AU - Antonia Schaffner AU - Urs Duthaler AU - Eric Grouzmann AU - Cédric M. Hysek AU - Matthias E. Liechti Y1 - 2015/04/01 UR - http://jpet.aspetjournals.org/content/353/1/102.abstract N2 - 3,4-Methylenedioxymethamphetamine (MDMA; “ecstasy”) is a popular recreational drug. The aim of the present study was to explore the role of dopamine in the psychotropic effects of MDMA using bupropion to inhibit the dopamine and norepinephrine transporters through which MDMA releases dopamine and norepinephrine. The pharmacodynamic and pharmacokinetic interactions between bupropion and MDMA in 16 healthy subjects were investigated using a double-blind, placebo-controlled, crossover design. Bupropion reduced the MDMA-induced elevations in plasma norepinephrine concentrations and the heart rate response to MDMA. In contrast, bupropion increased plasma MDMA concentrations and prolonged its subjective effects. Conversely, MDMA increased plasma bupropion concentrations. These results indicate a role for the transporter-mediated release of norepinephrine in the cardiostimulant effects of MDMA but do not support a modulatory role for dopamine in the mood effects of MDMA. These results also indicate that the use of MDMA during therapy with bupropion may result in higher plasma concentrations of both MDMA and bupropion and enhanced mood effects but also result in lower cardiac stimulation. ER -