PT  - JOURNAL ARTICLE
AU  - Detlef Neumann
AU  - Erich H. Schneider
AU  - Roland Seifert
TI  - Analysis of Histamine Receptor Knockout Mice in Models of Inflammation
AID  - 10.1124/jpet.113.204214
DP  - 2014 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 2--11
VI  - 348
IP  - 1
4099  - http://jpet.aspetjournals.org/content/348/1/2.short
4100  - http://jpet.aspetjournals.org/content/348/1/2.full
SO  - J Pharmacol Exp Ther2014 Jan 01; 348
AB  - The diverse functions of histamine are mediated by four specific histamine receptor subtypes, which belong to the family of G-protein-coupled receptors. Here, we summarize data obtained with histamine-deficient l-histidine decarboxylase knockout and histamine receptor subtype knockout mice in inflammation models. Advantages and disadvantages of the knockout approaches compared with pharmacologic approaches are discussed critically. Due to many controversial data it is very difficult to draw clear-cut conclusions from the data provided in the literature. Thus, the published studies highlight the complexity of histamine function in inflammation and the need for much more systematic experimental work.