PT  - JOURNAL ARTICLE
AU  - Arjun Jain
TI  - Endothelin-1–Induced Endoplasmic Reticulum Stress in Disease
AID  - 10.1124/jpet.113.205567
DP  - 2013 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 163--172
VI  - 346
IP  - 2
4099  - http://jpet.aspetjournals.org/content/346/2/163.short
4100  - http://jpet.aspetjournals.org/content/346/2/163.full
SO  - J Pharmacol Exp Ther2013 Aug 01; 346
AB  - The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a cellular stress induced by multiple stimuli and pathologic conditions. Recent evidence implicates endothelin-1 (ET-1) in the induction of placental ER stress in pregnancy disorders. ER stress has previously also been implicated in various other disease states, including neurodegenerative disorders, diabetes, and cardiovascular diseases, as has ET-1 in the pathophysiology of these conditions. However, to date, there has been no investigation of the link between ET-1 and the induction of ER stress in these disease states. Based on recent evidence and mechanistic insight into the role of ET-1 in the induction of placental ER stress, the following review attempts to outline the broader implications of ET-1–induced ER stress, as well as strategies for therapeutic intervention based around ET-1.