RT Journal Article
SR Electronic
T1 PHARMACOLOGY OF A NEW AUTONOMIC GANGLION BLOCKING AGENT, 2, 6-DIMETHYL-1, 1-DIETHYL PIPERIDINIUM BROMIDE (SC-1950)
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 435
OP 443
VO 99
IS 4
A1 COOK, DONALD L.
A1 HAMBOURGER, W. E.
A1 BIANCHI, ROBERT C.
YR 1950
UL http://jpet.aspetjournals.org/content/99/4/435.abstract
AB Pharmacological actions of a new autonomic ganglion blocking agent, 2,6-dimethyl-1, 1-diethyl piperidinium bromide (SC-1950), are described. These chiefly result from autonomic ganglion blockade. SC-1950 averages about five to seven times as effective as tetraethylammonium bromide in blocking the superior cervical (sympathetic) ganglion of the cat and the pelvic nerve (parasympathetic) ganglion of the dog. SC-1950 reduces intestinal tone and contractility in anesthetized and unanesthetized dogs, following preliminary increase in tone. These effects are more pronounced on the circular than on the longitudinal muscle of the ileum of the anesthetized dog. It has little effect on acetylcholine spasm of the excised rabbit ileum. Intravenous injections into anesthetized dogs produce a fall in blood pressure which is more prolonged with pentobarbital than with ether anesthesia. SC-1950 exhibits a curare-like blockade on the frog muscle-nerve preparation. Large doses also produce curare-like effects in unanesthetized rabbits and dogs. Acute toxicity data for mice, rats and dogs are given. 1950 by The American Society for Pharmacology and Experimental Therapeutics