RT Journal Article
SR Electronic
T1 A QUANTITATIVE STUDY OF BLOOD PRESSURE RESPONSE TO CARDIOVASCULAR DRUGS AND THEIR ANTAGONISTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 401
OP 408
VO 99
IS 4
A1 GRAHAM CHEN
A1 DAVID RUSSELL
YR 1950
UL http://jpet.aspetjournals.org/content/99/4/401.abstract
AB The graphical solutions of mass action equations by Lineweaver and Burk for monomolecular, competitive, and noncompetitive reactions have been utilized to study pharmacological reactions on blood pressure. Competitive inhibition is shown for epinephrine-SY 28, epinephrine-yohimbine, acetylcholine-atropine, and histamine-diphenhydramine. Noncompetitive inhibition is indicated with a large quantity of SY 28. Ergotamine antagonizes the vasodepressor response to histamine uncompetitively. The usefulness and limitations in the quantitation and elucidation of pharmacological reactions by the mass action law are pointed out. 1950 by The American Society for Pharmacology and Experimental Therapeutics