RT Journal Article
SR Electronic
T1 THE LEVATOR ANI MUSCLE OF THE RAT AS AN INDEX OF MYOTROPHIC ACTIVITY OF STEROIDAL HORMONES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 38
OP 44
VO 99
IS 1
A1 Eugene Eisenberg
A1 Gilbert S. Gordan
YR 1950
UL http://jpet.aspetjournals.org/content/99/1/38.abstract
AB 1. The effects of castration and of various steroids upon the weight and water content of the levator ani muscle of the male rat were studied. This muscle is notably smaller in the castrate than in the normal rat at 60 days and can be restored to normal weight, or even rendered hypertrophic, by the administration of certain steroids. 2. The response in weight of the levator ani muscle to administration of various steroids parallels closely their known protein-anabolic activity. The myotrophic effect is distinct from the androgenic effect. 3. By this assay, pituitary growth hormone, unesterified testosterone, testosterone propionate and methyl testosterone are potent myotrophic agents; progesterone is moderately active; and estradiol dipropionate, cis-testosterone, desoxycorticosterone acetate, and ethinyl testosterone produce no significant increase in weight of the muscle.