PT  - JOURNAL ARTICLE
AU  - TAYLOR, J. D.
AU  - RICHARDS, R. K.
AU  - EVERETT, G. M.
AU  - BERTCHER, ELIZABETH L.
TI  - EFFECT OF TRIDIONE (3,3,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE) ON THE OXYGEN UPTAKE OF MOUSE BRAIN
DP  - 1950 Apr 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 392--399
VI  - 98
IP  - 4
4099  - http://jpet.aspetjournals.org/content/98/4/392.short
4100  - http://jpet.aspetjournals.org/content/98/4/392.full
SO  - J Pharmacol Exp Ther1950 Apr 01; 98
AB  - 1. The effect of 0.035, 0.07, and 0.14 M Tridione on the inhibition of oxygen uptake of mouse brain slices with glucose, lactate, pyruvate, succinate, glutamate, citrate and acetate was studied. 2. At the lowest concentration, inhibition was present only with glucose. At the higher concentrations, inhibition was present with all substrates, although succinate was the least inhibited. 3. The inhibition with glucose could be overcome by washing, p-phenylenediamine, and methylene blue but not by ascorbic acid, glutathione, cysteine, adenosinetriphosphate or cytochrome c. 4. Brain slices from mice injected with large doses of Tridione showed inhibition of oxygen uptake in glucose. 5. Tridione acted like other central nervous system depressants in inhibiting the oxygen uptake when glucose, lactate, and pyruvate were substrates. With p-phenylenediamine and succinate the inhibition was considerably less. 1950 by The American Society for Pharmacology and Experimental Therapeutics