PT  - JOURNAL ARTICLE
AU  - KIMURA, K. K.
AU  - UNNA, K. R.
TI  - CURARE-LIKE ACTION OF DECAMETHYLENE-BIS-(ATROPINIUM IODIDE)
DP  - 1950 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 286--292
VI  - 98
IP  - 3
4099  - http://jpet.aspetjournals.org/content/98/3/286.short
4100  - http://jpet.aspetjournals.org/content/98/3/286.full
SO  - J Pharmacol Exp Ther1950 Mar 01; 98
AB  - 1. The action of decamethylene-bis-(atropinium iodide) possessing the same inter-atomic distance between the quaternary N atoms as d-tubocurarine and decamethylene-bis-(trimethylammonium iodide) was compared with d-tubocurarine C-10, atropine sulfate, atropine methyl nitrate and pentamethylene-bis-(atropinium iodide) for its curare-like and atropine-like effects. 2. In rabbits, this compound was five times more potent than pentamethylene-bis-(atropiniuin iodide), 140 times more potent than atropine methyl nitrate, and about twice as potent as d-tubocurarine. 3. The curarizing effects of this compound were readily antagonized by neostigmine. 4. Twinning of quaternary atropine molecules through a decamethylene chain also enhanced the specific peripheral atropine effects. The compound was about twice as potent as atropine methyl nitrate in blocking the effects both of vagal stimulation and of parasympathomimetic agents on the heart. 1950 by The American Society for Pharmacology and Experimental Therapeutics