PT - JOURNAL ARTICLE AU - J. Wolff AU - L. Rubin AU - I. L. Chaikoff TI - THE INFLUENCE OF 2,4-DINITROPHENOL ON PLASMA PROTEIN-BOUND IODINE DP - 1950 Jan 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 45--48 VI - 98 IP - 1 4099 - http://jpet.aspetjournals.org/content/98/1/45.short 4100 - http://jpet.aspetjournals.org/content/98/1/45.full SO - J Pharmacol Exp Ther1950 Jan 01; 98 AB - 1. 2,4-Dinitrophenol (DNP) was injected intraperitoneally into rats for 1 to 29 days. A characteristic finding in all rats so treated was a lowering in the concentrations of protein-bound iodine of plasma to approximately half those found in the control animals. 2. This fall in the level of plasma protein-bound iodine was not accompanied by an enlargement of the thyroid gland nor by a change in its histological appearance. Moreover, the amounts of total and thyroxine-like iodine of the gland were unaffected. The uptake of injected I131 and its conversion to organic forms by the thyroid gland of DNP-treated rats remained normal.