RT Journal Article
SR Electronic
T1 THE INFLUENCE OF DIPHENHYDRAMINE·HC1 (BENADRYL) ON APOMORPHINE-INDUCED EMESIS IN DOGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 245
OP 250
VO 98
IS 3
A1 CHEN, GRAHAM
A1 ENSOR, CHARLES R.
YR 1950
UL http://jpet.aspetjournals.org/content/98/3/245.abstract
AB Diphenhydramine·HCl (Benadryl) has been found to have an antiemetic effect against apomorphine-induced vomiting in dogs. Diphenhydramine-8-chlorotheophylline in equivalent doses of diphenhydramine is equally effective while 8-chlorotheophylline is ineffective in suppressing emesis. Phenobarbital and atropine are effective only in hypnotic doses. The mode of action of diphenhydramine·HCl in anti-emesis and its indication in pernicious vomiting of pregnancy, and in sea and air sickness are suggested. 1950 by The American Society for Pharmacology and Experimental Therapeutics