PT  - JOURNAL ARTICLE
AU  - GRAHAM CHEN
AU  - CHARLES R. ENSOR
TI  - THE INFLUENCE OF DIPHENHYDRAMINE·HC1 (BENADRYL) ON APOMORPHINE-INDUCED EMESIS IN DOGS
DP  - 1950 Mar 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 245--250
VI  - 98
IP  - 3
4099  - http://jpet.aspetjournals.org/content/98/3/245.short
4100  - http://jpet.aspetjournals.org/content/98/3/245.full
SO  - J Pharmacol Exp Ther1950 Mar 01; 98
AB  - Diphenhydramine·HCl (Benadryl) has been found to have an antiemetic effect against apomorphine-induced vomiting in dogs. Diphenhydramine-8-chlorotheophylline in equivalent doses of diphenhydramine is equally effective while 8-chlorotheophylline is ineffective in suppressing emesis. Phenobarbital and atropine are effective only in hypnotic doses. The mode of action of diphenhydramine·HCl in anti-emesis and its indication in pernicious vomiting of pregnancy, and in sea and air sickness are suggested. 1950 by The American Society for Pharmacology and Experimental Therapeutics