RT Journal Article
SR Electronic
T1 THE EFFECT OF PENICILLIN UPON THE CLOTTING ACTIVITY OF BLOOD IN NORMAL HUMAN SUBJECTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 291
OP 294
VO 96
IS 3
A1 Dolkart, Ralph E.
A1 Halpern, Bernard
A1 Larkin, Mary
A1 Dey, Frederick L.
A1 de Takats, G.
YR 1949
UL http://jpet.aspetjournals.org/content/96/3/291.abstract
AB 1. The effect of penicillin on the clotting activity of blood was measured in 24 normal subjects before and after the administration of 300,000 units of crystalline penicillin G in wax and oil. There was no significant alteration in the clotting time, prothrombin time, or heparin tolerance curve. 2. Similar results were obtained with four normal subjects following the administration of 300,000 units of crystalline penicillin G in saline. 3. It is concluded that penicillin G has no effect on the clotting activity of blood in normal human subjects.