TY - JOUR T1 - THE FATE OF TWO ARSENOXIDES IN THE DOG JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 250 LP - 257 VL - 96 IS - 3 AU - Thomas H. Maren Y1 - 1949/07/01 UR - http://jpet.aspetjournals.org/content/96/3/250.abstract N2 - 1. A colorimetric method for the determination of o-aminophenols has been described. This has been applied to plasma and urine to determine the o-amino-phenol component after the administration of oxophenarsine to dogs. Parallel determinations of the arsenic content were performed. 2. Oxophenarsine was found to be relatively unstable in the dog, existing as such for only three to six hours. 3. Similar studies were carried out for m-amino-p-carbamylphenylarsenoxide, using determinations of arylamino group and arsenic. The results suggest that this compound is relatively stable, and may circulate as such for 12-24 hours. ER -