RT Journal Article
SR Electronic
T1 A NEUROPHARMACOLOGICAL STUDY ON THE EFFECT OF MYANESIN (TOLSEROL) ON MOTOR SYSTEMS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 331
OP 341
VO 97
IS 3
A1 ELWOOD HENNEMAN
A1 ARNOLD KAPLAN
A1 KLAUS UNNA
YR 1949
UL http://jpet.aspetjournals.org/content/97/3/331.abstract
AB New techniques have been described whereby drugs affecting the extrapyramidal system may be tested. With them it has been demonstrated that: (1) Myanesin decreases or abolishes facilitation and inhibition reaching anterior horn cells from all levels of the C.N.S. (2) Neural circuits containing internuncial cells are vulnerable to Myanesin, whereas "direct" circuits withstand large doses without effect. (3) Relief of spasticity by Myanesin can be explained in terms of these effects. (4) The site of action of Myanesin is probably the internuncial cell. 1949 by The American Society for Pharmacology and Experimental Therapeutics