PT  - JOURNAL ARTICLE
AU  - ELWOOD HENNEMAN
AU  - ARNOLD KAPLAN
AU  - KLAUS UNNA
TI  - A NEUROPHARMACOLOGICAL STUDY ON THE EFFECT OF MYANESIN (TOLSEROL) ON MOTOR SYSTEMS
DP  - 1949 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 331--341
VI  - 97
IP  - 3
4099  - http://jpet.aspetjournals.org/content/97/3/331.short
4100  - http://jpet.aspetjournals.org/content/97/3/331.full
SO  - J Pharmacol Exp Ther1949 Nov 01; 97
AB  - New techniques have been described whereby drugs affecting the extrapyramidal system may be tested. With them it has been demonstrated that: (1) Myanesin decreases or abolishes facilitation and inhibition reaching anterior horn cells from all levels of the C.N.S. (2) Neural circuits containing internuncial cells are vulnerable to Myanesin, whereas "direct" circuits withstand large doses without effect. (3) Relief of spasticity by Myanesin can be explained in terms of these effects. (4) The site of action of Myanesin is probably the internuncial cell. 1949 by The American Society for Pharmacology and Experimental Therapeutics