TY - JOUR T1 - A NEUROPHARMACOLOGICAL STUDY ON THE EFFECT OF MYANESIN (TOLSEROL) ON MOTOR SYSTEMS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 331 LP - 341 VL - 97 IS - 3 AU - ELWOOD HENNEMAN AU - ARNOLD KAPLAN AU - KLAUS UNNA Y1 - 1949/11/01 UR - http://jpet.aspetjournals.org/content/97/3/331.abstract N2 - New techniques have been described whereby drugs affecting the extrapyramidal system may be tested. With them it has been demonstrated that: (1) Myanesin decreases or abolishes facilitation and inhibition reaching anterior horn cells from all levels of the C.N.S. (2) Neural circuits containing internuncial cells are vulnerable to Myanesin, whereas "direct" circuits withstand large doses without effect. (3) Relief of spasticity by Myanesin can be explained in terms of these effects. (4) The site of action of Myanesin is probably the internuncial cell. 1949 by The American Society for Pharmacology and Experimental Therapeutics ER -