RT Journal Article
SR Electronic
T1 THE EFFECTS OF VARIOUS FLAVONE GLUCOSIDES ON THE RATE OF PASSAGE OF EVANS BLUE THROUGH THE DAMAGED CAPILLARY WALL
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 243
OP 249
VO 97
IS 2
A1 DAVID F. BOHR
A1 BARBARA C. McIVOR
A1 JAMES F. RINEHART
YR 1949
UL http://jpet.aspetjournals.org/content/97/2/243.abstract
AB 1) The influence of various flavones on the rate of diffusion of Evans blue through the capillary wall damaged by heat was determined in an attempt to assay the effect of these materials on capillary permeability. 2) Rutin was about 40 per cent as effective as hesperidin methyl chalcone (H.M.C.) in producing a delay in skin colorization time. Sodium hesperidin chalcone was about 30 per cent as effectiveas H.M.C. 3) Evidence was presented which suggests that the delay in colorization time produced by these flavones was due largely to a decrease in capillary blood flow in the skin and hence cannot be used to evaluate changes in permeability of the capillary wall. 4) H.M.C. produced a greater and more sustained fall in blood pressure than did the other flavones.