TY - JOUR T1 - THE ADDICTION LIABILITY OF SOME DERIVATIVES OF MEPERIDINE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 182 LP - 190 VL - 97 IS - 2 AU - HARRIS ISBELL Y1 - 1949/10/01 UR - http://jpet.aspetjournals.org/content/97/2/182.abstract N2 - In sufficient dose, bemidone, keto-bemidone, Nu-1196, Nu-1779, and Nu-1932 induce morphine-like euphoria in former morphine addicts, and relieve abstinence from morphine. All these compounds must be regarded as addictive. Volunteers experimentally addicted to keto-bemidone exhibited morphine-like regressive behavior and developed tolerance to a number of actions of the drug. Following withdrawal of keto-bemidone, an abstinence syndrome, qualitatively similar to abstinence from morphine but quantitatively more severe, appeared very rapidly.Keto-bemidonehas very great addiction liability. © 1966 by The Williams & Wilkins Co. ER -