TY - JOUR T1 - THE ANTISPASMODIC ACTION OF BASIC NITRILES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 1 LP - 10 VL - 96 IS - 1 AU - A. M. Lands AU - Estelle Ananenko AU - Gwendolyn Jones AU - James O. Hoppe AU - T. J. Becker Y1 - 1949/05/01 UR - http://jpet.aspetjournals.org/content/96/1/1.2.abstract N2 - 1. The methiodide salts of various diphenylaminoalkanenitriles have significant anticholinergic activity. 2. The nitrite group appears to be important for this anticholinergic action. 3. The most active quaternary salts in this group of compounds are effective antispasmodics when administered parenterally, sublingually or orally. 4. Acute intravenous toxicity of these quaternary salts in albino mice is relatively high; by contrast oral toxicity of two of these is low. ER -