RT Journal Article
SR Electronic
T1 PHARMACOLOGICAL STUDIES ON THE CAUSATIVE AGENT OF CANINE HYSTERIA
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 429
OP 437
VO 95
IS 4
A1 JACK L. RADOMSKI
A1 GEOFFREY WOODARD
YR 1949
UL http://jpet.aspetjournals.org/content/95/4/429.abstract
AB 1. The dose-time curve of agene-treated gluten was found to resemble a hyperbola. The value for the threshold daily dose for accumulation to occur was found to be 70 mgm./kgm. for the dog and approximately 0.5 to 1.0 gm./kgm. or seven to fourteen times as great for the rabbit. These may be compared to acute toxicity values of 3.5 gm./kgm. for the dog and 10 gm./kgm. for the rabbit. 2. A considerable residue of the toxic effect tending to produce increased sensitivity on repeated administration remained after an interval of ten days. 3. The previous administration of agene-treated gluten in doses sufficient to produce ataxia lowers the threshold of reaction to metrazol. This reaction has properties of both canine hysteria and metrazol convulsion. 4. Hydration produced by the administration of water does not appear to precipitate fits in dogs administered sub-effective doses of agene-treated gluten. 5. Neither the administration of ammonium chloride nor sodium citrate affects the production of canine hysteria by agene-treated gluten. 6. Neither diphenylhydantoin nor trimethadione suppresses canine hysteria. Diphenyihydantoin and possibly also trimethadione potentiate the production of convulsions and death by agene-treated gluten. 7. Phenobarbital antagonizes the production of canine hysteria. 1949 by The American Society for Pharmacology and Experimental Therapeutics