RT Journal Article
SR Electronic
T1 THE ALTERED BLOOD-PRESSURE RESPONSE AFTER ADRENOLYTIC DRUGS AND LARGE DOSES OF SYMPATHOMIMETIC AMINES
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 415
OP 420
VO 95
IS 3
A1 I. A. CORET
A1 H. B. van DYKE
YR 1949
UL http://jpet.aspetjournals.org/content/95/3/415.abstract
AB After an adrenolytic drug, the depressor response to epinephrine can be temporarily transformed into a pressor response if a large dose of a sympathetic depressor amine such as the isopropyl homologue of epinephrine (Isuprel) or ethylnorepinephrine (Butanephrine) first be given. Simultaneously, there is no vascular response to previously effective doses of the particular depressor amine used. This blocking of depressor responses is termed tapenolysis sympathotapenolysis in a strict sense). Experiments with other sympathomimetic amines are described. The best tapenolytic agents are Isuprel and Butanephrine. A large dose of epinephrine can be both tapenolytic and adrenolytic. An explanation of tapenolysis is offered. 1949 by The American Society for Pharmacology and Experimental Therapeutics