RT Journal Article
SR Electronic
T1 FURTHER PHARMACOLOGIC CHARACTERIZATION OF THE SYMPATHOMIMETIC, ALIPHATIC AMINE 2 METHYLAMINO- 6-HYDROXY-6-METHYL HEPTANE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 352
OP 355
VO 96
IS 4
A1 Robert P. Walton
A1 Morris Belkin
YR 1949
UL http://jpet.aspetjournals.org/content/96/4/352.abstract
AB 2 Methylamino-6-hydroxy-6-methyl heptane was found to be of a low order of chronic toxicity and to be without important species differences with regard to acute toxicity. The LD50 of intravenously injected doses in mice, rabbits and dogs was approximately 350 times greater than the dose which has been described as producing in dogs an approximately 30 per cent increase in contractile force of the heart (10). Acute toxicity appeared to be based chiefly on central nervous system stimulation, although in animals surviving for some hours after large intravenously administered doses, lung consolidation was commonly observed. The drug exhibited weak mydriatic action, relative absence of effect on gut movements recorded with intestinal fistula dogs and relative absence of effects on central nervous system when used in the lower dose range.