RT Journal Article
SR Electronic
T1 CARDIO-VASCULAR EFFECTS OF TWO ALIPHATIC AMINES AND OF EPHEDRINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 343
OP 351
VO 96
IS 4
A1 Robert P. Walton
A1 Oliver J. Brodie
YR 1949
UL http://jpet.aspetjournals.org/content/96/4/343.abstract
AB 2-Methylamino-6-hydroxy-6-methyl heptane produced in dogs pressor effects and cardiac stimulation when given in doses five to ten times greater than those producing comparable effects with ephedrine. In contrast to ephedrine and 6-methylamino-2-methyl-2-heptene, this compound produced a distinctly lesser degree of cardiac depression when given in large or repeated doses. Similar relations of cardiac depression for these three amines were demonstrated in the isolated rabbit heart, although the distinctions were not so pronounced.