PT  - JOURNAL ARTICLE
AU  - Robert P. Walton
AU  - Oliver J. Brodie
TI  - CARDIO-VASCULAR EFFECTS OF TWO ALIPHATIC AMINES AND OF EPHEDRINE
DP  - 1949 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 343--351
VI  - 96
IP  - 4
4099  - http://jpet.aspetjournals.org/content/96/4/343.short
4100  - http://jpet.aspetjournals.org/content/96/4/343.full
SO  - J Pharmacol Exp Ther1949 Aug 01; 96
AB  - 2-Methylamino-6-hydroxy-6-methyl heptane produced in dogs pressor effects and cardiac stimulation when given in doses five to ten times greater than those producing comparable effects with ephedrine. In contrast to ephedrine and 6-methylamino-2-methyl-2-heptene, this compound produced a distinctly lesser degree of cardiac depression when given in large or repeated doses. Similar relations of cardiac depression for these three amines were demonstrated in the isolated rabbit heart, although the distinctions were not so pronounced.