PT  - JOURNAL ARTICLE
AU  - GIMBLE, ABRAHAM I.
AU  - DAVISON, CLARKE
AU  - SMITH, PAUL K.
TI  - STUDIES ON THE TOXICITY, DISTRIBUTION AND EXCRETION OF EMETINE
DP  - 1948 Dec 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 431--438
VI  - 94
IP  - 4
4099  - http://jpet.aspetjournals.org/content/94/4/431.short
4100  - http://jpet.aspetjournals.org/content/94/4/431.full
SO  - J Pharmacol Exp Ther1948 Dec 01; 94
AB  - 1. The LD50 of emetine in mice was 62 mgm. per kgm. and in rats, 17 mgm. per kgm. 2. The relative concentrations of emetine in rat and dog tissues were similar and were of the following order: liver > kidney > spleen > lung > brain > heart > skeletal muscle > blood. 3. Emetine was stored in the tissues of mice, rats, and dogs and was very slowly destroyed or excreted. 4. Emetine was not excreted in the urine to any appreciable extent. 1948 by The American Society for Pharmacology and Experimental Therapeutics