TY - JOUR T1 - THE TRACHEAL CHAIN JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 412 LP - 415 VL - 94 IS - 4 AU - JULIO C. CASTILLO Y1 - 1948/12/01 UR - http://jpet.aspetjournals.org/content/94/4/412.abstract N2 - 1. Tracheal chains made from guinea pigs sensitized to horse serum respond to relatively low concentrations of the antigen with prompt contractions which are maintained at the same level for a long period of time. 2. These anaphylactic spasms are not relaxed by antihistamine drugs but are relaxed by bronchodilator drugs. 3. The anaphylactic spasm, as produced in the guinea pig trachea, differs from that produced by histamine, not only in its resistance to antihistamine drugs but also in the fact that the anaphylactic spasm cannot be relaxed by washing. 1948 by The American Society for Pharmacology and Experimental Therapeutics ER -