RT Journal Article
SR Electronic
T1 DIATROPINE DERIVATIVES AS PROOF THAT d-TUBOCURARINE IS A BLOCKING MOIETY CONTAINING TWIN ATROPINE-ACETYLCHOLINE PROSTHETIC GROUPS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 149
OP 154
VO 95
IS 2
A1 K. K. Kimura
A1 Klaus Unna
A1 Carl C. Pfeiffer
YR 1949
UL http://jpet.aspetjournals.org/content/95/2/149.abstract
AB Diatropines, whether synthesized by quaternization through the nitrogen atoms or by connecting the tropic acid hydroxyl groups by an aliphatic chain, have a markedly increased curare-like potency which approaches that of d-tubocurarine. Compounds with slight atropine-like activity become curare-like when two molecules are connected by an alkyl chain of suitable length. When the oxygen prosthetic groups are joined a chain of 9 A length should be used while a chain of 15 A length is probably optimal for joining the nitrogen atoms.