TY - JOUR T1 - ADRENERGIC BLOCKING DRUGS: III. EFFECTS OF TWO HALOGENATED ETHYLAMINES ON PRESSOR RESPONSES TO EPINEPHRINE, NICOTINE AND ADRENERGIC NERVOUS REFLEXES JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 350 LP - 358 VL - 94 IS - 4 AU - CLEM A. STONE AU - EARL R. LOEW Y1 - 1948/12/01 UR - http://jpet.aspetjournals.org/content/94/4/350.abstract N2 - N-(2-bromoethyl)-N-ethyl-l-naphthalenemethylamine·HBr and N-2-(2-biphenylyloxy)ethyl-N-(2-chloroethyl)butylamine·HCl, in relatively small doses of 1.0 and 5.0 mgm./kgm., intravenously, respectively, have been shown to be active adrenergic blocking compounds by virtue of the ability to reverse the action of epinephrine and to diminish or block the pressor responses to anoxia, carotid occlusion, and small doses of nicotine in dogs. The experimental evidence supports a peripheral adrenergic blocking action. 1948 by The American Society for Pharmacology and Experimental Therapeutics ER -