RT Journal Article
SR Electronic
T1 THE PHARMACOLOGICAL PROPERTIES OF THREE NEW ANTIHISTAMINIC DRUGS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 45
OP 52
VO 95
IS 1
A1 A. M. Lands
A1 James O. Hoppe
A1 O. H. Siegmund
A1 F. P. Luduena
YR 1949
UL http://jpet.aspetjournals.org/content/95/1/45.abstract
AB 1. WIN 2848 is a highly active antagonist of histamine and is more potent in its antihistaminic actions than are the chioro- and bromo- substituted analogs, WIN 2875 and WIN 2876. 2. The antihistaminic drugs investigated here stimulate the isolated guinea pig uterus. 3. WIN 2848, in a dose of 0.013 mgm./kgm., protects guinea pigs against 2.8 intravenous lethal doses of histamine. 4. WIN 2848 diminishes the effects of histamine given percutaneously to man. 5. WIN 2848 does not appear to be significantly more toxic than structurally similar antihistaminic drugs.