PT  - JOURNAL ARTICLE
AU  - A. GOLDIN
AU  - H. A. NOE
AU  - B. H. LANDING
AU  - D. M. SHAPIRO
AU  - B. GOLDBERG
TI  - A NEUROLOGICAL SYNDROME INDUCED BY ADMINISTRATION OF SOME CHLORINATED TERTIARY AMINES
DP  - 1948 Nov 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 249--261
VI  - 94
IP  - 3
4099  - http://jpet.aspetjournals.org/content/94/3/249.short
4100  - http://jpet.aspetjournals.org/content/94/3/249.full
SO  - J Pharmacol Exp Ther1948 Nov 01; 94
AB  - 1. A series of nitrogen mustard analogues were studied and the essential structural groupings necessary to produce the neurological syndrome of waltzing in mice were identified. 2. The compounds which produced the waltzing syndrome were dialkyl and heterocyclic-beta-chloroethylamines. 3. No waltzing was elicited when the following structural modifications were made: a) Substitution of a hydroxyl group for the beta chlorine. b) Substitution of a beta-phenyl group for one of the beta hydrogens in the chlorinated chain. c) Substitution of bromine for the beta chlorine. d) Introduction of phenyl groups into the dialkyl carbons. 4. Primary and secondary beta-chloroethylamines; related quaternary compounds; and bis, tris, and tetrakis beta-chioroethylamines did not elicit the effect. 5. Two compounds similar in structure to both the mono-beta-chloroethyl amines and bis(beta-chloroethyl)amines produced transient waltzing. 6. Cerebellar and axial lesions found in induced waltzers could account for the behavior pattern of the mice. 7. The chemical relationships of these compounds and their mechanism of action are discussed. 1948 by The American Society for Pharmacology and Experimental Therapeutics