RT Journal Article
SR Electronic
T1 STUDIES ON DIETHYLAMINOETHANOL
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 18
OP 27
VO 95
IS 1
A1 Benjamin Rosenberg
A1 Herbert J. Kayden
A1 Philip A. Lief
A1 Lester C. Mark
A1 J. Murray Steele
A1 Bernard B. Brodie
YR 1949
UL http://jpet.aspetjournals.org/content/95/1/18.abstract
AB Diethylaminoethanol, a product of the hydrolysis, in vivo, of procaine, was studied in various cardiac arrhythmias. It protected dogs under cyclopropane anesthesia from the development of ventricular premature contractions and ventricular tachycardia. It suppressed ventricular premature contractions for a short period, in human subjects. Six cases of ventricular tachycardia were successfully reverted by the drug. No effect was noted on auricular fibrillation or supraventricular tachycardia. Diethylaminoethanol is considerably less active than procaine. The effective dose however is much safer than the correspondingly effective dose of procaine. The physiological disposition of diethylaminoethanol was studied in man. About 25 per cent of the drug was excreted in the urine; the remainder was metabolized by an unknown route. A single dose is almost completely metabolized or excreted in 8 hours. Considerable amounts of the compound are localized in the organs of the body (dog).