PT  - JOURNAL ARTICLE
AU  - SYDNEY ELLIS
TI  - ENZYMIC HYDROLYSIS OF MORPHINE ESTERS
DP  - 1948 Oct 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 130--135
VI  - 94
IP  - 2
4099  - http://jpet.aspetjournals.org/content/94/2/130.short
4100  - http://jpet.aspetjournals.org/content/94/2/130.full
SO  - J Pharmacol Exp Ther1948 Oct 01; 94
AB  - 1. The activities of the plasma and liver of the rabbit on monoacetylmorphine, benzoylcholine and atropine are due to three separate enzymes. 2. The above conclusion is based on the following observations: the relative activities on the three substrates of plasma as compared with liver; the distribution of the various enzymes in the tissues and bloods of other animals; and the differences in sensitivity of the various activities to esterase inhibitors, to heat and to drying with acetone. 3. The hydrolysis of the 3-acetyl group of heroin appears to be a function of tributyrinase, but not of the enzymes which hydrolyze methylbutyrate, acetyl-choline, or acetylsalicylic acid. 1948 by The American Society for Pharmacology and Experimental Therapeutics