RT Journal Article
SR Electronic
T1 A STUDY OF THE PHARMACOLOGICAL RELATIONSHIP BETWEEN DIGITOXIN AND HISTAMINE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 53
OP 59
VO 94
IS 1
A1 A. Sjoerdsma
A1 E. Kun
YR 1948
UL http://jpet.aspetjournals.org/content/94/1/53.abstract
AB 1. Following the intravenous injection of digitoxin (1 mgm./kgm.) into rabbits the blood histamine level decreased. 2. Histamine dihydrochloride (1:1,000,000) greatly potentiated the lethal effect of digitoxin (1:40,000) on the isolated hearts of rabbits, cats and guinea pigs. The hearts of rats were resistant under these experimental conditions. 3. Histamine dihydrochloride (1:1,000,000) exerted a diphasic action on the the coronary outflow of isolated hearts. The hearts of cats, guinea pigs and rats exhibited an initial coronary dilatation while a constriction was observed in the case of rabbit hearts. 4. In joint toxicity studies on guinea pigs digitoxin and histamine dihydrochloride acted synergistically in producing death of the animals.