RT Journal Article
SR Electronic
T1 THE FATE OF ACETANILIDE IN MAN
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 29
OP 38
VO 94
IS 1
A1 Brodie, Bernard B.
A1 Axelrod, Julius
YR 1948
UL http://jpet.aspetjournals.org/content/94/1/29.abstract
AB The route of metabolism of acetanilide in man was shown to be as follows: a minor fraction of the drug deacetylates to form aniline; this compound was shown to be the precursor of the substance which oxidizes hemoglobin to methemoglobin; the major fraction of the drug is oxidized to N-acetyl p-aminophenol; this compound is excreted in a conjugated form. The analgesic action of acetanilide is exerted mainly through N-acetyl p-aminophenol which is an active analgesic. The oxidation of acetanilide occurs mainly in the liver.