TY - JOUR T1 - THE CURARIFORM ACTIVITY OF d-N-METHYL-CHONDRODEN DRINE AND d-O-METHYL-N-METHYL-CHONDRODENDRINE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 109 LP - 113 VL - 93 IS - 1 AU - David F. Marsh AU - Clark K. Sleeth AU - Eldon B. Tucker Y1 - 1948/05/01 UR - http://jpet.aspetjournals.org/content/93/1/109.abstract N2 - d-N-Methyl-chondrodendrine iodide and d-O-methyl-N-methyl-chondroden-drine iodide were compared with d-tubocurarine chloride pentahydrate and d-O-methyltubocurarine iodide trihydrate in rats, rabbits, cats, and man. d-N-Methyl-chondrodendrine (as the ion) is about one-half as paralysant as the isomeric d-tubocurarine in rats and rabbits, although only one-fourth to one-eighth as active in cats and man. d-O-Methyl-N-methyl-chondrodendrine is about equipotent with d-tubocurarine, but it is only one-sixth to one-eighth as active as its diastereosiomer, d-O-methyltubocurarine. All of these compounds have relatively little effect in intact animals other than lissive action on skeletal muscles. ER -