TY - JOUR T1 - THE PHARMACOLOGY OF COMPOUNDS STRUCTURALLY RELATED TO HYDROXYTYRAMINE JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 369 LP - 380 VL - 92 IS - 4 AU - A. M. LANDS AU - V. L. NASH AU - B. L. DERTINGER AU - H. R. GRANGER AU - H. M. McCARTHY Y1 - 1948/04/01 UR - http://jpet.aspetjournals.org/content/92/4/369.abstract N2 - 1. Racemic nor-epinephrine is distinctly more pressor than racemic epinephrine. 2. Inhibitory (sympathin I-mimetic) actions of nor-epinephrine are increased by N-alkyl substitution. 3. The structure of the N-alkyl group is an important factor influencing inhibitory potency. 4. Inhibitory effects are not prominent with those hydroxytyramine derivatives that do not contain the alcoholic hydroxyl of nor-epinephrine. 5. The significance of these findings is discussed. 1948 by The American Society for Pharmacology and Experimental Therapeutics ER -