PT  - JOURNAL ARTICLE
AU  - C. C. Scott
AU  - E. B. Robbins
AU  - K. K. Chen
TI  - PHARMACOLOGIC COMPARISON OF THE OPTICAL ISOMERS OF METHADON
DP  - 1948 Jul 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 282--286
VI  - 93
IP  - 3
4099  - http://jpet.aspetjournals.org/content/93/3/282.short
4100  - http://jpet.aspetjournals.org/content/93/3/282.full
SO  - J Pharmacol Exp Ther1948 Jul 01; 93
AB  - 1. The analgesic action of l-Dolophine is much greater than that of the d-isomer, the order of activity being approximately 7.5:1 in rats, 25:1 in dogs, and 50:1 in man. 2. l-Dolophine produces more narcosis than the d-form in equianalgesic doses. 3. In anesthetized dogs, l-Dolophine is 25 times as depressant to respiration, but 65 times as stimulating to duodenum, as the d-isomer. 4. There is little difference in toxicity between the l- and d-isomers in mice by intravenous injection. Either optical isomer is, however, slightly less toxic than the racemic mixture.