RT Journal Article
SR Electronic
T1 THE EFFECT OF CERTAIN GOITROGENIC DRUGS ON THE ABSORPTION OF RADIOACTIVE IODINE BY THE THYROID GLAND
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 246
OP 257
VO 93
IS 2
A1 D. A. McGinty
A1 R. W. Rawson
A1 R. G. Fluharty
A1 Mary Wilson
A1 Charlotte Riddell
A1 Hilda Yee
YR 1948
UL http://jpet.aspetjournals.org/content/93/2/246.abstract
AB The antithyroid action of several goitrogenic compounds was studied quantitatively by comparing the effect and duration of effect of varying doses of these agents, when injected subcutaneously, on the collection of radioiodine by the thyroids of rats and chicks. The drugs studied included thiouracil, propylthiouracil, benzylthiouracil, methylthiouracil, 5-aminothiadiazole-2-thiol (TC-68), 3-(phenylaminomethyl)-thiazolidine-2-thione (TC-105), 2-aminothiazole and potassium thiocyanate. In the rat, it was observed that propyl and benzylthiouracil were ten times as effective as thiouracil and methylthiouracil in inhibiting the thyroid's natural capacity to collect iodine. The duration of inhibitory action of minimal effective doses of these drugs was not materially different. In all cases at least partial escape from the drug effect occurred eight hours after administration. In the cockerel, the minimal effective inhibitory doses of all compounds were greater than in the rat. Benzylthiouracil was observed to be approximately ten times more effective than thiouracil, propylthiouracil and TC-68. TC-105 aminothiazole and potassium thiocyanate had about one-half the activity of thiouracil. The duration of action of minimal effective doses was six hours. With the exception of aminothiazole, in all instances escape from the block to iodine collection was complete 24 hours after injection of the drug. Certain fundamental differences between the iodine-blocking effect and the goitrogenic action of these agents are discussed.