RT Journal Article
SR Electronic
T1 NIAARA; A DIGITALIS-LIKE COLOMBIAN ARROW POISON
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 223
OP 229
VO 93
IS 2
A1 K. Mezey
A1 C. Uribe-Piedrahita
A1 J. Pataki
A1 J. Huertas-Lozano
YR 1948
UL http://jpet.aspetjournals.org/content/93/2/223.abstract
AB 1. Niaara, an arrow poison from Colombia, S. A. is the latex of the tree Ogcodeia ternstroemiiflora Midbr. 2. An amorphous principle ("niaarin") having chemical and pharmacological properties characteristic of the cardiac glycosides has been isolated from the latex of this tree. Neither the crude nor pure materials have any curariform activity. 3. The intravenous LD50 in cats is 0.21 mgm./kgm. It is poorly absorbed from the gastro-intestinal tract. 4. Seven cases of congestive heart failure in man were successfully treated with niaarin.