PT  - JOURNAL ARTICLE
AU  - N. ERCOLI
AU  - WILLIAM WILSON
TI  - INFLUENCE OF BAL ON THE TOXICITY AND CHEMOTHERAPEUTIC ACTIVITY OF MAPHARSEN
DP  - 1948 Feb 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 121--126
VI  - 92
IP  - 2
4099  - http://jpet.aspetjournals.org/content/92/2/121.short
4100  - http://jpet.aspetjournals.org/content/92/2/121.full
SO  - J Pharmacol Exp Ther1948 Feb 01; 92
AB  - The therapeutic activity of Mapharsen, under the influence of BAL, has been studied in relation to its toxicity in mice infected with T. equiperdum. It was found that: 1) The curative activity of the arsenical is inhibited by much lower doses of BAL than the trypanocidal activity. 2) The therapeutic activity of the arsenical is inhibited by relatively lower doses of BAL than the toxicity, as measured by the mortality figures. 3) In general, the higher the dose of the arsenical the more BAL proportionately is required for inhibition. 4) The extremely fast decrease in the curative action of Mapharsen, when given in conjunction with BAL, precludes the possibility of this form of combined chemotherapy. 1948 by The American Society for Pharmacology and Experimental Therapeutics